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  5. Role of the NO / sGC / PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory

Role of the NO / sGC / PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory

来源 :第十五届中国神经精神药理学学术会议 | 被引量 : 0次 | 上传用户：mena
【摘 要】
：
Although evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) signaling pathway in the hippocampal CA1 region plays a key role in memory proc
【作 者】
：
SHEN Fang LI Yi-jing SHOU Xiao-jing CUI Cai-lian 
【机 构】
：
Neuroscience Research Institute, Peking University;Department of Neurobiology, School of Basic Medic
【出 处】
：
第十五届中国神经精神药理学学术会议
【发表日期】
：
2012年8期
【关键词】
：
nitric oxide signaling pathway morphine reward memory hippocampus 
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　　Although evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) signaling pathway in the hippocampal CA1 region plays a key role in memory processing, it remains unclear wheth er this signaling cascade is involved in drug-induced reward memory.In this study, we investigated the role of the NO/sGC/PKG signaling pathway in the CA1 on morphine-induced reward memory using a conditioned place preference (CPP) paradigm.
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