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  5. Saponins from Panax japonicus ameliorates cognition deficits and attenuates oxidative damage in D-ga

Saponins from Panax japonicus ameliorates cognition deficits and attenuates oxidative damage in D-ga

来源 :第十五届中国神经精神药理学学术会议 | 被引量 : 0次 | 上传用户：robitewx
【摘 要】
：
Aging is an inevitable process featured by intelligence decline, behavioral disorders and cognitive disability.Increasing evidence indicates that oxidative stress plays a key role in the se nescent de
【作 者】
：
WANG Ting DI Guo-jie ZHANG Chang-cheng YUAN Ding 
【机 构】
：
Department of Pharmacology, Medical College of Three Gorges University , Yichang 443002, China
【出 处】
：
第十五届中国神经精神药理学学术会议
【发表日期】
：
2012年8期
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　　Aging is an inevitable process featured by intelligence decline, behavioral disorders and cognitive disability.Increasing evidence indicates that oxidative stress plays a key role in the se nescent development.Our previous study demonstrated that Sap onins from Panax japonicus has a significant anti-oxidative effect in vitro.So the aim of the present study was to investigate the brain protective role of Saponins from Panax japonicus and its un derlying mechanism.Mice were subcutaneously injected with D galactose (D-gat, 150 mg·kg-1 ·d-1) for 8 weeks and adminis tered Saponins from Panax japonicus simultaneously.After 8weeks of treatment, the animal behavior was observed in the open field test and water maze test, and the morphology of hippo campus was detected.The activities and mRNA expressions of antioxidant enzymes as well as the level of malondialdehyde(MDA) were evaluated.
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