Conjugated Polymer Grafted with H2O2-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing

来源 :中国化学会生物物理化学专业委员会第四届全国生物物理化学会议 | 被引量 : 0次 | 上传用户：lujundehao

【摘要】

：

　　A new conjugated polymer poly(fluorene-co-phenylene)derivative containing pendent quaternized chlormethine(PFP-Chl)was synthesized by covalent linking small

【作者】

：

刘礼兵李梦吕凤婷王树

【机构】

：

InstituteofChemistry,CAS

【出处】

：

中国化学会生物物理化学专业委员会第四届全国生物物理化学会议

【发表日期】

：

2016年6期

【关键词】

：

Conjugated Polymer Cell Imaging Tumor Cell Killing

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　　A new conjugated polymer poly(fluorene-co-phenylene)derivative containing pendent quaternized chlormethine(PFP-Chl)was synthesized by covalent linking small molecular prodrug groups onto conjugated polymer side chains.H2O2-sensitive prodrug with an eight-member-cyclic boronate ester structure could suffer from H2O2-triggered nitrogen mustard release and further DNA cross-linking and alkylation.

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Conjugated Polymer Grafted with H2O2-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing

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