Loss of cell adhesion molecule CHL1 improves homeostatic adaptation and survival in hypoxic stress

• 作 者: 黄欣;WeifangRong;TongZhao;LiyingWu;linglingZhu;MingFan;
• 机 构: 军事医学科学院基础医学研究所军事认知研究室
• 出 处: 中国生理学会第24届全国会员代表大会暨生理学学术大会
• 发表日期: 2014年期

　　Objective CHL1 is a transmembrane cell adhesion molecule that is critical for brain development and in the maintenance of neural circuits in the adult.Recent studies revealed that CHL1 has diverse roles and is involved in the regulation of recovery after spinal cord injury.CHL1 expression was down-regulated in the cerebral cortex,hypothalamus and brain stem after induction of acute hypoxia.In the current study we sought to address the role of CHL1 in regulating homeostasis responses to hypoxia using CHL1 knockout(CHL1?/?)mice.