Apelin induces vascular smooth muscle cells migration through PI3K/Akt/FoxO3a/MMP-2 pathway

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：ydaf4rx3

【摘要】

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【作者】

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Jianyan Wen Cheng Wang Yun Zhou Li Li Xiaobing Cui Jinyu Wang Lin Pan Zhidong Ye Peng Liu Liling Wu

【机构】

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Department of Cardiovascular Surgery, China-Japan Friendship Hospital

【出处】

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2014年第十二届全国脂质与脂蛋白学术会议

【发表日期】

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2014年7期

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Apelin is a novel discovered adipokines that plays critical role in the development of atherosclerosis (AS), that may offer potential for the therapy of AS.Since migration of vascular smooth muscle cells (VSMCs) is a key event in the development of atherosclerosis, it is important to understand the effect of apelin on atherosclerotic vasculature.Here we investigated the effect of apelin on VSMCs migration and explored the possible signaling mechanism.In the cultured rat VSMCs, apelin promoted VSMCs migration in a dose-and time-dependent manner.

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Apelin induces vascular smooth muscle cells migration through PI3K/Akt/FoxO3a/MMP-2 pathway

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