Visualization & Quantification: Internal Structure of the DDS and Release Kinetics of TCM Dosage

• 作 者: X.Z.Yin[1]H.Y.Li[1]Q.Shao[2]P.York[2]T.Q.Xiao[3]Y.He[3]J.W.Zhang[1]
• 机 构: Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
• 出 处: 中华中医药学会制剂分会、世界中联中药药剂专业委员会2011学术年会暨“龙津杯”中药制剂创新与发展论坛
• 发表日期: 2011年期

Aims: The visualization techniques are especially of importance in analysis for the release kinetics of either drug delivery system (DDS) with complex internal structure or that of a natural product as Traditional Chinese Medicines (TCM) dosage form with multiple components. Though the internal structural characteristics of an osmotic pump DDS are obviously relevant to the release kinetics, yet the quantitative methodology for correlation of structural parameters with release kinetics should be developed with the aid of visualization techniques. We also tried to establish a visualized procedure to overview and quantify the multiple component release kinetics of the TCM dosage forms, which are beyond of the conventional dissolution / release methods.