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Background: With the using of tumor immunotherapy in the clinical treatment, a lot of problems were founded such as the factor of the tumor microenviroment, the suppressed anti-tumor immunocells and the poor long term treatment effect.We built the second load tumor model of SCID/beige nude mice to recur the tumor microenviroment in beginning of tumor development and recurrence.Specific umbilical blood Dc vaccines were used to stimulate the function of the immunocells and reduce the inhibition of tumor immune effector cells in tumor mincroenviroment.