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Background: Role of laparoscopic resection for large (especially larger than 5 cm) gastric GIST is still in debate for the fear of intraoperative tumor rupture.Methods: To determine the feasibility and safety of laparoscopic approach in treatment of large gastric GIST,a prospective study was carried out between March 2011 and March 2015.Intraoperative tumor rupture was studied as primary outcome.Secondly outcomes were conversion rate, operating time, estimated blood loss, time of tolerate fluid and solid diet, length of postoperative hospital stay and recurrence rate at the end of the follow-up.