【摘 要】
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Objective Based on the intervention of alcohol, SP600125 was used to block the JNK signaling pathway in H9C2 cells,to observe the changes in the level of Histone H3 acetylation and over-expression of
【机 构】
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Children's hospital of chongqing medical university
【出 处】
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第17届中国南方国际心血管病学术会议
论文部分内容阅读
Objective Based on the intervention of alcohol, SP600125 was used to block the JNK signaling pathway in H9C2 cells,to observe the changes in the level of Histone H3 acetylation and over-expression of downstream cardiac specific genes caused by alcohol exposure, to explore whether JNK mediated the effects of intervention by alcohol in H9C2 cells.In this study, we test the hypothesis that JNK signaling pathway mediated the hyper-acetylation of histone H3 and over-expression of cardiac specific genes induced by alcohol exposure.
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