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Rationale Idiopathic pulmonary fibrosis (IPF) is an incurable fibrosing disorder that progresses relentlessly to respiratory failure.Follistatin-like 1 (FSTL1), a TGF-b1-induced matricellular protein, has previously been shown in our lab as a profibrotic factor whose deletion in mice is protected from bleornycin-induced pulmonary fibrosis.