日本鳗鲡IL-10基因的鉴定与表达分析

来源 :中国水产学会鱼病专业委员会2015年学术讨论会 | 被引量 : 0次 | 上传用户:ggfjkjtyr
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  白细胞介素10(Interleukin-10,IL-10)是一类多效应细胞因子,不仅能够调节机体免疫反应,还能抑制机体炎症反应。本研究运用RACE 方法克隆得到日本鳗鲡IL-10(AjIL-10)基因(Ajil10),其cDNA 全长为1499 bp,开放阅读框546 bp,可编码一个181 肽的前体蛋白质,该蛋白质N-末端含有一个23 氨基酸残基的信号肽,C-末端含有IL-10 家族特征性的保守基序“GX2KAX2EX2LLFX2IE”。
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