【摘 要】
：
Low molecular mass (MM)chitosan with high degree of deacetylation (DDA) has excellent bioactivity including targeting drug delivery,antibacterial and encapsulation properties.Thus,to reduce MM of chit
【机 构】
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College of Food Science and Technology, Shanghai Ocean University, No 999 Huchenghuan Road, Lingang
论文部分内容阅读
Low molecular mass (MM)chitosan with high degree of deacetylation (DDA) has excellent bioactivity including targeting drug delivery,antibacterial and encapsulation properties.Thus,to reduce MM of chitosan and increase its DDA,microwave-assisted heating extraction (UAHE) conditions on the (MM) and degree of deacetylation (DDA) were investigated in this study using three factors,three levels Box-Behnken (BB) response surface design.Selected parameters including microwave heating time,H2O2 concentration and solid-liquid ratio,which significantly affect the degree of deacetylation and molecular mass of chitosan.The results showed that the observation DDA and MM were fitted to a second-order polynomial equation using multiple regression analysis and have high coefficient of predicted value (R2 =0.965).An optimization study was performed using Derringers desired function methodology and the optimal conditions involves microwave heating time of 120 s,H2O2 concentration of 2% and solid-liquid ratio of 1∶40.This study indicated that low MM of chitosan with high DDA can be applied to drug encapsulation and releasing carrier,food antibacterial and antioxidant agents.
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