【摘 要】
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It is generally known that risk variants segregate together with a disease within families, but this information has not been used in the existing statistical methods for detecting rare variants.Here
【机 构】
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Department of Epidemiology and Biostatistics, Case Western Reserve University 2103 Cornell Road, sui
【出 处】
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The Third IMS-China International Conference on Statistics a
论文部分内容阅读
It is generally known that risk variants segregate together with a disease within families, but this information has not been used in the existing statistical methods for detecting rare variants.Here we introduce two weighted sum statistics that can apply to either genome-wide association data or resequencing data for identifying rare disease variants: weights calculated based on sibpairs and odd ratios, respectively.
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