Design platinum (Ⅳ) prodrugs of cisplatin and oxaliplatin with long lipid chains for drug delivery a

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：kinganguo

【摘要】

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【作者】

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Qiling Chen Yuanyuan Yang Xiaoli Pan Peng Zhao Zheng Cai Ruiyuan Liu Ling Lu Zhiqiang Yu

【机构】

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School of Pharmaceutical Sciences,Guangdong Provincial Key Laboratory of New Drug Screening,Southern

【出处】

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Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

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2016年11期

【关键词】

：

drug delivery platinum(Ⅱ) platinum(Ⅳ) prodrug nanoparticles resistance

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　　Drug resistance,both inherent and acquired,is a major drawback and the main reason for the failure of Pt drugs[1].To overcome drug resistance,various non-classical platinum drugs have been synthesized,including multinuclear platinum and platinum(Ⅳ) (Pt(Ⅳ)) drugs[2].However,it is still a challenge to load cisplatin and oxaliplatin into conventional nano-carriers due to the lack of both hydrophobicity and hydrophilicity.

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Design platinum (Ⅳ) prodrugs of cisplatin and oxaliplatin with long lipid chains for drug delivery a

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