黄藤素注射液抗LPS致小鼠急性肺损伤的作用研究

来源 :2016年全国抗炎免疫药理学术会议 | 被引量 : 0次 | 上传用户：genersoft

【摘要】

：

目的:研究黄藤素抗脂多糖致小鼠急性肺损伤的作用.方法:健康雄性成年昆明小鼠随机分为6组:正常对照组;LPS组(气管滴入脂多糖LPS 5 mg/kg);氢化可的松组(腹腔注射氢化可的松3.3mg/kg,每日一次,连续三天,第四天气管滴入LPS 5mg/kg);黄藤素低、中、高剂量组(分别腹腔注射黄藤素2mg/kg、10 mg/kg和50 mg/kg,每日一次,连续三天,第四天气管滴入LPS 5mg/

【作者】

：

张旋王永艳杨桂梅王应霞胡艳文姚珊

【机构】

：

昆明医科大学药学院暨云南省天然药物药理重点实验室,云南,昆明650500 昆明医科大学第一附属医院

【出处】

：

2016年全国抗炎免疫药理学术会议

【发表日期】

：

2016年11期

【关键词】

：

黄藤素急性肺损伤炎症内皮细胞自噬

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Sustained elevation of NF-κB activity sensitizes offspring of maternal inflammation tohypertension v

Growing evidence has demonstrated that maternal detrimental factors, including inflammation,contribute to the development of hypertension in the offspring.The current study found that offspring subjec

会议

Temporal expressions of cell cycle regulators mRNA during hypertrophic process of H9c2 rat cardiomyo

Aim: To observe the mRNA expressions of cell cycle regulators at different time point during the hypertrophic process of H9c2 rat cardiomyoctes induced by angiotensin 1Ⅱ stimulation.

会议

Cardiac hypertrophycardiomyocytescell cyclecyclincyclin dependent kinasep21

Astaxanthin inhibits lung fibrosis via down-regulation of TGF-β1-mediated Smads/ERK signaling pathwa

Objective: To investigate the effect of Astaxanthin (AX) on bleomycin (BLM)-induced lung fibrosis in rats and the underlying mechanism.Methods: Thirty-two healthy male SD rats were randomly divided in

会议

Astaxanthinlung fibrosisbleomycinTGF-β1

Research of HLXK on liver fibrosis in mice

Aim: To explore the effect and mechanism of HLXK on liver fibrosis in mice.Methods: 36 male mice were randomly divided into 6 groups, including control group, hepatic fibrosis model group, positive dr

会议

Effect of triptolide on hypertrophic response and expression of P53 in neonatal rat ventricular myoc

Objective: To investigate the effects of triptolide on the hypertrophic response and expression of P53 in neonatal rat ventricular myocytes (NRVM).Methods: NRVMs were isolated from neonatal SD rats, a

会议

Neonatal myocardial cellsHypertrophyTriptolideP53

孕期炎症刺激致子代小鼠免疫系统异常与动脉粥样硬化发生的关系研究

目的:孕期炎症刺激导致子代成年小鼠对心血管疾病的危险因素敏感性增高,从而诱发严重的心血管事件,然而其具体机制目前尚不清楚.本研究旨在探究孕期炎症刺激是否导致子代小鼠动脉粥样硬化的发生及其机制.

会议

Temporal expressions of cell cycle regulators mRNA during hypertrophic process of H9c2 cells induced

Aim: To observe the mRNA expressions of cell cycle regulators at different time point during the hypertrophic process of H9c2 cells induced by angiotensin Ⅱ.

会议

cardiac hypertrophycardiomyocytescell cyclecyclincyclin dependent kinasep21

miR-135a-5p抑制肺动脉平滑肌细胞中TRPC1的表达降低大鼠肺动脉高压

肺动脉高压(PAH)以肺血管重构为显著特征,其中肺动脉平滑肌细胞异常增殖是构成肺动脉血管重构的主要病理基础.TRPCs是PASMCs细胞膜上的非选择性阳离子通道超家族,对维持细胞内外钙离子浓度具有重要作用,抑制其表达可抑制肺血管重构,缓解肺动脉高压的发生.

会议

Pharmacodynamics and immune regulation mechanism of Dangguiliuhuang decoction against insulin resist

Background: Insulin resistance (IR) plays a central role in the development of diabetes and is also a low degree of chronic metabolic inflammation.The obesity and abnormal lipids metabolism increases

会议

Danguiliuhuang decoctionInsulin resistancePPAR-γPI3K/Akt

Expression and release of microglial proinflammatory cytokine IL-6 and the effect of CysLT1R antagon

Objective: To determine whether the neurotoxin rotenone induces expression and release ofmicroglial proinflammatory cytokine interleukin-6 (IL-6), and whether the selective cysteinyl leukotriene recep

会议

interleukin-6microgliacysteinyl leukotriene receptor 1antagonistrotenone

黄藤素注射液抗LPS致小鼠急性肺损伤的作用研究

其他学术论文