MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3

• 作 者: NaHuang[1]RongchengLuo[1]JingLin[2]JianRuan[1]NingSu[3]RuzhaiQing[1]FeiyeLiu[1]BenfuHe[1]ChengweiLv[1]DayongZheng[1]
• 机 构: Department of Oncology, Nanfang Hospital of Southern Medical University, Guangzhou,Guangdong Provinc
• 出 处: 2012年全国肿瘤分子标志学术大会与国际肿瘤转化医学论坛暨第七届中国中青年肿瘤专家论坛
• 发表日期: 2012年期

　　MicroRNAs (miRNAs) have been linked to the molecular pathogenesis of many cancers,acting as tumor suppressors or oncogenes.In this study, we found that miR-219-5p was significantly downregulated in 83 HCC tissues and three HCC cell lines, compared to their non-tumor counterparts.MiR-219-5p expression was correlated with tumor size (P =0.027), histological differentiation (P =0.030), and overall survival time (P =0.005)in HCC patients.We also found that miR-219-5p could inhibit cell proliferation in vitro.Further studies identified that miR-219-5p reduced both the mRNA and protein levels of glypican-3 (GPC3).These findings indicate that miR-219-5p exerts tumor-suppressive effects in hepatic carcinogenesis through negative regulation of GPC3 expression.