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An internal solitary wave as high as 100 m has been reported in the South China Sea (SCS).Large-amplitude internal waves may cause severe damage to the ocean engineering and submarine.In this paper,with the assumption that the fluid is in a two-layer stratification system,the fully-nonlinear Schrodinger equation (FNLS) that describes large-amplitude internal wave propagation in deep sea is derived from the governing equations of hydrodynamics by introducing the perturbation expansions.Finally,numerical simulation is carried out in South China Sea and the result is in accordance with optical MODIS images,so our model is suitable for simulating the large-amplitude internal wave behavior in deep sea.