Chronic exposure to cigarette smoke extract decreased PTGIS expression in pulmonary artery endotheli

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：roseisdead

【摘要】

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【作者】

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Tao Wang Linhua Pang Fuqiang Wen

【机构】

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Laboratory of Pulmonary Diseases,West China Hospital of Sichuan University

【出处】

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2016年国际生理学学术大会

【发表日期】

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2016年6期

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　　Objective: Cigarette smoke can directly acts on the pulmonary vasculature to induce endothelial dysfunction and pulmonary vascular remodeling.The aim of this study is to test our hypothesis that chronic cigarette smoke extract(CSE)exposure may be able to alter the expression of prostaglandin I2 synthase(PTGIS)which catalyzes the conversion of prostaglandin H2 to prostaglandin I2(prostacyclin),the most potent inhibitor of platelet aggregation and a strong vasodilator,through epigenetic modifications.

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Chronic exposure to cigarette smoke extract decreased PTGIS expression in pulmonary artery endotheli

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