【摘 要】
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Purpose: Glibenclamide has a newly discovered role in inflammation regulation besides its anti-diabetic effect.As an inhibitor of ATP-sensitive potassium(KATp)channel,glibenclamide antagonizes the rel
【机 构】
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Department of Critical Care Medicine,Second Affiliated Hospital,Zhejiang University School of Medici
【出 处】
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中华医学会2014年全国变态反应学术会议
论文部分内容阅读
Purpose: Glibenclamide has a newly discovered role in inflammation regulation besides its anti-diabetic effect.As an inhibitor of ATP-sensitive potassium(KATp)channel,glibenclamide antagonizes the relaxation of tracheal smooth muscle.These indicate that glibenclamide might attenuate airway inflammation while aggravate airway hyperresponsiveness (AHR) in asthmatics.Clinically,many diabetics with asthma are prescribed with glibenclamide to control blood glucose.However,it remains unknown whether glibenclamide could exert any effects on asthmatic inflammation.To address this,we investigated the role of glibenclamide in ovalbumin(OVA)-induced AHR,airway inflammation,and Th2 immune response in a mouse model of asthma.
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