【摘 要】
：
Kinases play pivotal role play pivotal roles in virtually all aspects of cellular physiology1.Potent and selective kinase inhibitors are highly desirable, both as tool compounds for dissecting complex
【机 构】
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State Key Laboratory of Cellular Stress Biology, School of Life Sciences, and State-province Joint E
【出 处】
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中国化学会第十届全国天然有机化学学术会议
论文部分内容阅读
Kinases play pivotal role play pivotal roles in virtually all aspects of cellular physiology1.Potent and selective kinase inhibitors are highly desirable, both as tool compounds for dissecting complex signaling pathways and as potential therapeutics for treating kinase-related diseases.Hence there is an urgent need to develop stategies that will allow for the rapid identification of kinase inhibitors of interest.A new strategy, compound centric kinome-wide profiling, enables rapid discovery of the full range of kinase-targets for a particular scaffold2.
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