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Purpose: The Jaw bone loss is associated with osteoporosis induced by imbalanced estrogen levels.The response of osteocyte to estrogen play an important role in jaw bone absorption and homeostasis.The reduction of the osteocyte autophagy is one of the important reasons of osteopenia.miRNA also play an important role in the regulation of bone formation and absorption.In metabolic bone diseases such as osteoporosis,the miRNA dysfunction is an important pathological factor.According the effect and mechanism of miRNA,specific knockout of the target gene of miRNA may be one of the effective means for the treatment of metabolic bone disease.