【摘 要】
：
Autophagy, as a process of lysosomal-dependent intracellular components degradation, is especially important in disorders where accumulation of the mutant p
【机 构】
：
Institute for Molecular and Cell Biology (IBMC),University of Porto,Porto,Portugal
【出 处】
：
2014 International Conference on Aging and Disease(2014年第一届衰
论文部分内容阅读
Autophagy, as a process of lysosomal-dependent intracellular components degradation, is especially important in disorders where accumulation of the mutant protein is a hallmark, such as Machado-Joseph disease (MJD/SCA3;OMIM 109150), a late onset progressive polyglutamine ataxia, considered the worldwide most common autosomal dominant polyQ SCA caused by a CAG tract expansion in the ATXN3 gene (OMIM 607047).Beclin 1 is one of the autophagy-related proteins, defects in which were found to be correlated with neurodegenerative diseases.
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