【摘 要】
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The tremella polysaccharide(TP) has significant cytokine-stimulating activity and was very big molecules.For studying its smallest active structure which shall be profitable in further utilization and
【机 构】
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Changchun University of Traditional Chinese Medicine, Key laboratory of macromolecules in Chinese me
【出 处】
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世界中医药学会联合会中药化学专业委员会第五届学术年会暨蒙医药论坛
论文部分内容阅读
The tremella polysaccharide(TP) has significant cytokine-stimulating activity and was very big molecules.For studying its smallest active structure which shall be profitable in further utilization and research, TP was hydrolyzed and fractionated to obtain the fragments which was broken down from its (1→3)-mannan backbone.The fragments were isolated with gel-filtration and HPLC chromatography, three oligosaccharide fractions (L-4-1, 2, 3), which composed with di-,tri-saccharides;tetra-, penta-saccharides;and hex-, hepta-.octa-saccharide, respectively, were obtained.The structures of those oligosaccharide were identified by component sugars,methylation and LC-MS analysis to be (1→3)-oligomannan which composed with 2 to 8 mannose residues in linear manner.The cytokine-stimulating experiment showed that the DP should be over 6 for keeping the activity in the oligomannan and the smallest structure was determined.
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