Novel bioengineered hydrogel combined with brain-derived neurotrophic factor and glial cell line-der

来源 :2nd International Neural Regeneration Symposium(INRS2012)(第二 | 被引量 : 0次 | 上传用户:free522
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The initial mechanical insult resulting from traumatic spinal cord injury (SCI) causes the disruption of local vasculature and tissue structure followed by a secondary wave of injury involving hemorrhage, ischemia, edema, excitotoxicity, and inflammation, which leads to neuronal death, axonal degeneration, and inhibitory glial scar formation.
其他文献
Neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, including stroke.
Hypoxia/ischemia induces neuronal death.Ways to protect neurons from death under the conditions of hypoxia/ischemia have been widely studied.
Calpain (μ-and m-) and ERK1/2 activation are strongly implicated in the pathophysiology of traumatic spinal cord injury (SCI).However, the contribution of either individual calpain/ERK isoforms or cro
Traumatic spinal cord injury (SCI) follows a two-phase pathological progression, starting with primary mechanical damage followed by secondary biochemical injury that expands the lesion over time.Foll
Stem cell therapy is a potential treatment for spinal cord injury (SCI) and a variety of different stem cell types have been grafted into humans suffering from spinal cord trauma or into animal models
Injury potential is a direct current potential difference between sites of spinal cord injury and normal tissue, and its initial amplitude is a significant indicator of the grade of spinal cord injury
Mouse bone marrow-derived macrophages and fetal brain-derived microglia were isolated and cultured in vitro, then administered myelin, a dominant proinflammatory mediator released after spinal cord in
Lingo-1 is selectively expressed in oligodendrocytes and neurons in the central nervous system (CNS), and is a key negative regulator of nerve regeneration.
Interneurons may play an important role in functional compensation and axonal regeneration after spinal cord injury.However, the mechanism underlying functional recovery is unclear.
Dexmedetomidine, a sedative/anesthetic drug is associated with a lower incidence of delirium and reduced length of ventilation after severe brain trauma.Dexmedetomidine has neuroprotective effects aga