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Traditional Chinese medicine (TCM) has been playing a very important role in health protection and disease control for thousands of years.Syndrome and formulae (prescription) are two important parts in TCM,however the vagueness of syndrome and complexity of formulae make the diagnosis and evaluation difficulty,greatly limited the research progress on the effective substances and pharmacological mechanism of TCM.Furthermore,due to the complexity of the components in formulae and for the lack of an effective systematic approach,it is still a challenge to identify the effective components,to elucidate the mechanism of the components and to discover the relationship between syndrome and formulae.We have conducted the innovative methodology research for TCM,aim to solve the key scientific issues such as biological essence of syndrome and effective substances of formulae.A systematic method called Chinmedomics for discovery and identification of effective substance TCM formulae was proposed using serum pharmacochemistry of TCM integrated with metabolomics.Chinmedomics is the research method of mining the biological characters of syndrome and evaluating the efficacy of formulae, and then to shed new lights on the efficacy of formulae to discover effective constituents,and finally to elucidate the scientific value of TCM.