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Lysophospholipase D (lysoPLD),a lipid mediator,is known to convert lysophosphatidyclcholine (LPC) to lysophosphatidic acid (LPA),which is known to be inhibited by LPA in a feed-back mechanism.Previously,it was reported that hen egg white contains polyunsaturated fatty acid-rich LPA.In this study,we examined the inhibitory effect of twenty fish egg extracts,containing various lipids,on the bovine lysoPLD activity.