真菌沉默次生代谢基因调控的研究

来源 :2015年上海市研究生学术论坛(生物化工) | 被引量 : 0次 | 上传用户：eciling

【摘要】

：

微生物来源的天然产物在现代药物研发过程中起着关键作用,尤其是在肿瘤,感染,脂代谢失调以及免疫缺陷疾病的治疗过程中,次生代谢产物一直被证明是新型治疗药物以及先导化合物的持久而有效的来源(J.Nat.Prod.2012,75,311).随着基因组测序技术的飞速发展,多种微生物的全基因组信息已经被阐明,但研究发现,在正常实验室培养条件下,微生物体内大部分次生代谢基因处于"沉默"状态,即低表达或者不表达,

【作者】

：

代广知谭仁祥

【机构】

：

南京大学生命科学学院,江苏省南京市栖霞区仙林大道163号

【出处】

：

2015年上海市研究生学术论坛(生物化工)

【发表日期】

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2015年11期

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