论文部分内容阅读
新型水溶性氟苯尼考磷酸双酯前药的设计与合成
【机 构】
：
武汉工程大学 化工与制药学院,湖北 武汉 430073
【出 处】
：
全国药物化学学术会议暨第四届中英药物化学学术会议
【发表日期】
：
2013年11期
其他文献
Design,Synthesis and Biological Evaluation of Non-peptide αvβ3/α5β1 Integrin Dual Antagonists Contai
Malignant tumor is one of the main diseases that threaten humans health and life.The metastasis and multidrug resistance of tumor cells to chemotherapy agents are the mainly difficult problems in clin
会议
Multi-Criteria Molecular Design:What can we learn from recent successes? Lead Hopping,Scaffold Hoppi
Multiple biological and physical-chemistry parameters contribute to a commercially successful drug or agchem discovery program.These include adequate potency and selectivity,desirable ADME profile and
Discovery of dibenzofuran/carbazole derivatives as multifunctional anti-Alzheimer agents:acetylcholi
会议
HPLC Determination of the Binding Rate on Bovine Serum Albumin and Luteolin by Using Equilibrium Dia
会议
Design,Synthesis and in Vitro Study of Novel 4-Substituted-Neu5Ac2en Derivatives Against Influenza V
会议
以黄芩苷为起始原料,运用一步合成法,合成了基于黄芩素 A 环修饰物的衍生物—6,7-二乙酰氧基黄芩素,其结构通过IR,MS,13CNMR 和1HNMRS 数据确证。初步细胞增殖抑制实验(MTT 法)结果显示,与黄芩素(IC50=100μM)相比,6,7-二乙酰氧基黄芩素对肿瘤细胞株K562 的增殖具有明显抑制作用(IC50=50μM)。体外实验结果表明,黄芩素A 进行结构修饰的衍生物有可能发展成为
Among the building blocks for construction of fused N-heterocyclic quinazoline rings,3,4-dihydro-2H-pyrazino[2,1-b]quinazoline-1,6-dione(1)has been anticipated to be versatile in further structural mo
ATP 结合式转运蛋白的过度表达肿瘤细胞产生多药耐药(Multidrug resistance,MDR)的重要原因[1].其中,P-糖蛋白(P-glycoprotein,P-gp)及乳腺癌耐药蛋白(Breast cancerresistance protein,BCRP)的过度表达会导致多种化疗药物治疗失败,包括临床上广泛应用的酪氨酸激酶抑制剂.通过抑制P-gp 及BCRP 的功能和/或表达,可以