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Introduction: Obesity in men is frequently associated with testosterone deficiency.Adipose tissue is an active endocrine organ producing substances (e.g., estrogens, cortisol, leptin, inflammatory cytokines) that suppress endogenous testosterone production.This study analysed effects of normalization of testosterone in hypogonadal men.Methods: Open-label, single-center, cumulative, prospective registry study of 255 men (mean age 60.6 8.0 years), with testosterone levels≤3.5 ng/mL receiving parenteral testosterone undecanoate 1000 mg/12 weeks after an initial 6-week interval.Results: After 5 years the following changes occurred: testosterone increased from 2.87 ± 0.4 to 5.26 ± 0.44 ng/mL.Body weight (kg) decreased from 106.22 ± 16.93 (minimum: 70, maximum: 139) to 90.07 ± 9.51 (min 74.00, max 115).The statistical significance was p<0.0001 vs baseline and vs the previous year over 5 years indicating a continuous weight.Waist circumference (cm) declined from 107.24 ± 9.14 (min 86, max 129) to 98.46 ± 7.39 (min 84, max 117) (p<0.0001 vs baseline and vs the previous year over 5 years).Body mass index (BMI, m/kg2) declined from 33.93 ± 5.54 (min 21.91, max 46.51) to 29.17 ± 3.09 (min 22.7;max 36.7l) (p<0.0001 vs baseline and vs the previous year over 5 years).The mean per cent weight loss after 1 year was 4.12 ± 3.48%, after 2 years 7.47 ± 5.01%, after 3 years 9.01 ± 6.5%, after 4 years 11.26 ± 6.76% and after 5 years 13.21 ± 7.24%.At baseline, 96% of men had a waist circumference of ≥94 cm.This proportion decreased to 71% after 5 years.Conclusions: Normalising testosterone resulted in progressive loss of weight, waist circumference and BMI over the full 5 years of the study.