【摘 要】
：
乳腺癌脑转移是乳腺癌致死的主要原因之一,探寻这一过程的关键因子是预防及治疗乳腺癌脑转移的关键.FSTL1在多种肿瘤中表达异常,与多种乳腺癌脑转移相关蛋白存在相互作用
【机 构】
：
首都医科大学基础医学院,北京市,100069
论文部分内容阅读
乳腺癌脑转移是乳腺癌致死的主要原因之一,探寻这一过程的关键因子是预防及治疗乳腺癌脑转移的关键.FSTL1在多种肿瘤中表达异常,与多种乳腺癌脑转移相关蛋白存在相互作用,且我们在前期研究中发现FSTL1在乳腺癌脑转移细胞亚群中表达升高,这提示FSTL1可能与乳腺癌脑转移有相关性.此外,近期研究发现TGF-β信号通路在乳腺癌脑转移细胞中受抑制,而FSTL1可与TGF-β超家族的部分蛋白特异性结合,抑制TGF-β通路,这提示FSTL1可能通过调控TGF-β通路影响乳腺癌细胞向脑部转移.目前,FSTL1在乳腺癌脑转移中的研究尚未见报道,本课题拟从细胞和整体动物水平研究FSTL1在乳腺癌脑转移中的作用,并探寻其可能的分子机制,为预防及治疗脑转移提供理论基础.
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