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目的 Statins have been widely used ininflammatory diseases including asthma,because of their anti-inflammatory and immunomodulatory properties.It has been shown that simvastatin induce autophagy and cell death in some circumstances.However,the possible cross-talk between simvastatin and autophagic process in lung diseases is largely unknown.Thus,we investigated the impact of simvastatin on airway inflammation and airway remodeling and the possible relationship of these processes to a simvastatin-induced autophagic pathway in asthmatic mouse models.方法 OVA-sensitized and challenged mice were treated with simvastatin and sacrificed to death.