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  5. A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventr

A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventr

来源 :首都医科大学2013年研究生学术论坛 | 被引量 : 0次 | 上传用户：ghanfeng
【摘 要】
：
Parkinson s disease (PD) is characterized by selective and progressive degeneration of dopaminergic neurons in the substantia nigra (SN).Lipopolysaccharide (LPS) can induce chronic inflammation and ha
【作 者】
：
Yan Zhou Yanxin Zhang Junquan Li Fengyue Lv Yongmei Zhao Deyi Duan Qunyuan Xu 
【机 构】
：
Beijing Institute for Neuroscience, Beijing Center of Neural Regeneration and Repairing, Key Laborat
【出 处】
：
首都医科大学2013年研究生学术论坛
【发表日期】
：
2013年2期
【关键词】
：
cholinergic neurons dopaminergic neurons inflammation lipopolysaccharide Parkins 
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　　Parkinson s disease (PD) is characterized by selective and progressive degeneration of dopaminergic neurons in the substantia nigra (SN).Lipopolysaccharide (LPS) can induce chronic inflammation and has been widely used to study the pathogenesis of PD.In this study, a single intracerebroventricular injection of LPS was used to induce neurotoxic effects on dopaminergic neurons in Sprague-Dawley rats.
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