MeCP2 in autism- displays allelic expression imbalance and affects both nerve system and heart devel

• 作 者: YufangZheng[1]YumengWang[1]YahuiLiu[2]YasongDu[3]ZhangminYang[4]YanqingHe[4]XiaohongGong[2]XingLiu[5]JianHuang[5]BingSu[6]KepingHu[7]ZilongQiu[8]HongyanWang[2]
• 机 构: State Key Laboratory of Genetic Engineering, MOE Key Laboratory of Contemporary Anthropology, and Co
• 出 处: 2015中国遗传学会大会
• 发表日期: 2015年期

　　Both Autism and Rett syndrome are neural development disorders sharing certain characterizations such as impaired social interaction or communication, and the restricted and repetitive behavior.However, they have very different sexual bias as autism affects 4-5 boys versus 1 girl while Rett syndrome mainly affects girls with limited boys.Mutations of MeCP2 (Methyl-CpG-binding protein 2), a X chromosome gene, has been identified not only in most Rett syndrome patients, but also in autism patients.