Downregulated microRNA-93 inhibits VSV replication by facilitates the activation of interferon-JAK-S

• 作 者: MengGuo;FangLiu;XingZhang;JinHou;ShanjuanHong;XuetaoCao;QuanxingWang;
• 机 构: National Key Laboratory of Medical Immunology,Second Military Medical University,Shanghai 200433,Chi
• 出 处: 第八届全国免疫学学术大会
• 发表日期: 2012年期

　　Innate immune response has a critical role in the defense against invading virus.MiRNA is an emerging important regulator in host antiviral network.Based on our previous microarray analysis, in the present study, we showed that miR-93 was profoundly downregulated in antigen presenting cells (APCs) upon vesicular stomatitis virus (VSV) infection through RIG-I/JNK dependent but TLR/MyD88 independent pathways.Downregulation of miR-93 feedback attenuated virus replication.Moreover, miR-93 could target on JAK1 and suppress the activation of JAK-STAT signaling pathway, and subsequently inhibited the production of type Ⅰ IFN.Therefore, downregulation of miR-93 following VSV infection feedback positively regulates host antiviral innate immune response by facilitates the activation of interferon-JAK-STAT pathway.