Preparation of a New Thermo-sensitive Biocompatible Poly(N,N-dibutyl-L-glutamine) with LCST and UCST

• 作 者: XinMa;ZimingYin;HeyingDeng;TingJiang;XueyingFan;MengWang;KuilinDeng;
• 机 构: College of Chemistry & Environmental Science,Hebei University,Baoding 071002
• 出 处: 中国化学会第29届学术年会
• 发表日期: 2014年期

　　A new thermosensitive poly(N,N-dibutyl-L-glutamine)(PDBG)with good biocompatibility is designed and synthesized by polymerization of N,N-dibutyl-L-glutamine derived from natural L-glutamic acid.The chemical structures of the monomer and polymer are confirmed by FTIR and 1H NMR spectroscopy,and by elemental analysis measurements.Turbidimetric measurements indicate that PDBG has a lower critical solution temperature(LCST)at 37℃ in purified water.And,the polymer simultaneously exhibited reversible upper critical solution temperature(UCST)transition in ethanol/water solution.In addition,the evaluation of cell cytotoxicity by MTT method suggested that the survival rate of HeLa cells to PDBG reached to 85%within 48 h,and 72h.In conclusion,the novel thermosensitive PDBG with good biocompatibility could be a promising material in the biomedical applications.