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目的:为西北燥证主证动物实验选择合宜微观指标。方法:根据西北燥证临床和流行病学研究结果,寻觅选择微观实验指标的方向;学习既往中医动物实验文献,在选择方向引导下分析相关指标,加以初步筛选,得出一定数量的备选指标;以入选指数大小对备选指标进行加权计量取舍,从而选定适量指标。结果:从西北燥证主证寻出微观指标选择方向信息;初步选出76项微观指标为备选指标;通过公式推算了76项指标的计量选择参数和入选指数;截取入选指数大于0.5的18项指标确定为西北燥证主证动物实验微观指标。结论:微观指标加权计量选择法较既往经验判断法更加客观科学且便于规范操作,不仅适用于西北燥证研究,亦可成为在更广泛领域内开展中医复杂性病证研究选择实验指标之借鉴。
Objective: To select suitable micro-indicators for animal experiments of syndromes of North-west dryness syndromes. Methods: Based on the clinical and epidemiological findings of Northwest Dryness syndrome, we sought for the direction of selecting microscopic experimental indicators. Studying the experimental literature of previous TCM animals, analyzing the relevant indicators under the guidance of selection direction and preliminary screening, we obtained a certain number of alternative indicators ; Select the index based on the size of the selected index weighting choice, so as to select the appropriate number of indicators. Results: The micro-index selection direction information was found out from the main syndromes of North-west dryness syndromes; 76 micro-indicators were initially selected as the alternative indicators; 76 selection indicators and selected indices were calculated by formulas; Item indicators identified as the main northwest dryness witness animal micro-indicators. CONCLUSION: Compared with the past empirical judgments, the weighted index selection method of microscopic indicators is more objective and scientific and convenient for standardized operation. It can not only be applied to the research of the Northwest Dryness Syndrome, but also can be used as a reference to select the experimental indicators for the study of complex TCM syndromes in a wider area.