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Objective: This study aimed to evaluate the feasibility and necessity of No.13 lymph node dissection in D2 radical gastrectomy for lower-third advanced gastric cancer(AGC).Methods: Data of 379 cases who were diagnosed as TNM Ⅱ-Ⅲ stage AGC were collected from 2001 to 2007 in Tianjin Cancer Hospital.One hundred cases who undergone No.13 lymph node dissection during D2 gastrectomy for lower-third AGC were selected as study group.Other 279 cases (control group) received only D2 gastrectomy.The differences in clinicopathologic and intraoperative and postoperative parameters and 5-years survival rate were compared using the SPSS17.0 software.Results: There were no significant differences between the two groups in patients gender, age, tumor size, histologic type, Borrmann type, duodenum invasion, tumor depth, lymph node metastasis, TNM classification, operative time, blood loss and the incidence of postoperative complications(p > 0.05).In the study group, there were 9 patients with positive No.13 lymph node, and its 5-year survival rate was higher than the control group(p < 0.05).Univariable analysis showed that age, No.13 lymph node dissection, tumor size, duodenum invasion, tumor depth, lymph node metastasis, TNM classification were associated with prognosis of lower-third AGC(p < 0.05).Multivariate analysis identified age, tumor size, duodenum invasion, and tumor depth as independent prognostic factors(p < 0.05).Conclusions: No.13 lymph node dissection for TNM Ⅱ-Ⅲ stage lower-third advanced gastric cancer is feasible and necessary.