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Many bacteria produce low-molecular weight,high affinity iron chelators called siderophores in response to an iron-limiting environment,such as that found in a host organism.Salicylate serves as a building block for siderophores produced by a variety of human pathogens,including the siderophore pyochelin from Pseudomonas aeruginosa.P.aeruginosa synthesizes salicylate from chorismate in a two-step process:an isochorismate synthase (PchA) converts chorismate to isochorismate,which is in turn converted to salicylate by an isochorismate-pyruvate lyase (IPL) called PchB.PchB shows no sequence similarity to other pyruvate lyases,which proceed through a general base mechanism.