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Topographic representation of sound frequency in the primary auditory cortex, or tonotopy, is widely known.Using real-time imaging with voltage-sensitive dyes, we have demonstrated dynamic activity propagation in an isofrequency strip.Such activity can be induced by focal stimulation of the cortex, suggesting the anisotropic nature of the intrinsic circuit in the auditory cortex and the ability of such circuit in supporting activity propagation within an isofrequency strip.Consistent with this notion, a significant portion of spontaneous events in the primary auditory cortex showed similar spatiotemporal pattern to tone-evoked activity.To test whether focal stimulation of the cortex can induce auditory perception, we trained animals in a trace-learning paradigm and tested the effect of cortical stimulation.Cortical stimulation induced behavioral response conditioned with a tone after learning, but not after extinction.These findings should have implications on auditory prosthesis by cortical stimulation.