A chemical proteomic approach for characterization of doxorubicin-resistance associated proteins in

来源 :DaLian Internationall Symposia and Exhibition on Chromatogra | 被引量 : 0次 | 上传用户：qinyongj

【摘要】

：

【作者】

：

Ruijun Tian Mingliang Ye Hongwei Liu Houjiang Zhou Hong Ma Ling Yang Hanfa Zou

【机构】

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National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sc

【出处】

：

DaLian Internationall Symposia and Exhibition on Chromatogra

【发表日期】

：

2007年12期

【关键词】

：

Chemical proteomics Drug resistance Doxorubicin K562 cancer cell lines

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　　Resistance to antineoplastic drugs represents a major obstacle to the success of cancer chemotherapy.The mechanisms of drug resistance are polygenetic and yet to be completely defined.Successful development of effective drug resistance reversal agents is, therefore, heavily dependent on our understanding to the various target proteins and pathways involved in the emergence of drug resistance phenotype.

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A chemical proteomic approach for characterization of doxorubicin-resistance associated proteins in

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