Preparation of conductive Calcium phosphate cement and evaluation of the biocompatibility in vitro

来源 :第十一届全国表面工程大会暨第八届全国青年表面工程学术会议 | 被引量 : 0次 | 上传用户:asfaweawrv
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  Calcium phosphate cements (CPC) are highly valuable materials for the repair of bone defects with excellent biocompatibility and bioactivity. However, the use of CPC is restricted by their lack of macroporosity and poor osteogenic activity. In this paper, the conductive CPC were prepared by adding the reduced-graphene oxide (RGO) /PPy composites and the biocompatibility was studied by in vitro co-culture with the MC3T3-E1 osteoblasts under the stimulation of micro direct current. The relationship between the stimulation with different dc current and the cell performances in vitro had been investigated.The results show that when CPC were co-cultured with osteoblasts under the stimulation of micro direct current, there were better cell performances than that under no direct current sitmulation. When were co-cultured with osteoblasts under, Moreover, CPC exhibited the best biocompatibility in vitro under the stimulation of 10 mA direct current. Therefore,these conductive CPC can greatly increase the biocompability under the stimulation of micro direct current and will be a promising biomaterial for bone defect repairing.
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