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  5. Association between plastin 3 gene polymorphism and osteoporotic fracture in postmenopausal Chinese

Association between plastin 3 gene polymorphism and osteoporotic fracture in postmenopausal Chinese

来源 :第七届国际骨质疏松及骨矿盐疾病学术会议 | 被引量 : 0次 | 上传用户：ktv238
【摘 要】
：
Background: Plastin 3 (PLS3) gene is located on the X chromosome, encoding the actin-binding protein plastin 3,the protein is a member of protein family which responsible for the dynamic assembly and
【作 者】
：
Chong Shao Jinwei He Wenzhen Fu Chun Wang Zhenlin Zhang 
【机 构】
：
Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shan
【出 处】
：
第七届国际骨质疏松及骨矿盐疾病学术会议
【发表日期】
：
2014年3期
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Background: Plastin 3 (PLS3) gene is located on the X chromosome, encoding the actin-binding protein plastin 3,the protein is a member of protein family which responsible for the dynamic assembly and disassembly of actin cytoskeleton, recent studies found that mutations of the gene can lead to osteoporosis and fractures, and somewhat verified in the Rotterdam study population.The purpose of this study was to investigate the relationship between bone mineral density and PLS3 gene polymorphism and the risk of osteoporotic fractures in Chinese postmenopausal women.
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