【摘 要】
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Objectives:Chronic hepatitis C virus (CHC) infection is treated with interferon/ribavirin,but only a subset of patients respond.The molecular mechanism of i
【机 构】
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University of Toronto Canada
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Objectives:Chronic hepatitis C virus (CHC) infection is treated with interferon/ribavirin,but only a subset of patients respond.The molecular mechanism of interferon resistance is not well undertstood.We previously reported that treatment nonresponders have marked pre-treatment upregulation of a subset of interferon stimulated genes (ISGs) in their livers,including ISG 15 (Chen,et al.Gastroenterology 2005) and discovered ISG15/USP18 pathway is involved in interferon resistance (Randall,et al.Gastroenterology 2006).Here,we study the effect of ISG 15 on HCV production in J6/JFH 1 culture system.
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