Structural insights into the Ragulator-and EGO-TC-mediated membrane tethering of the mTORC1-regulato

来源 :中国生物化学与分子生物学会2019年全国学术会议 | 被引量 : 0次 | 上传用户：msdnolduser1

【摘要】

：

The Rag/Gtr GTPases serve as a central module in the nutrient-sensing signaling network upstream of TORC1.In human,the nutrient-activated Rag heterodimer binds to mTORC1 to promote its recruitment to

【作者】

：

Tianlong Zhang Marie-Pierre Péli-Gulli Rong Wang Zhen Zhang Claudio De Virgilio Jianping Ding

【机构】

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CAS Center for Excellence in Molecular Cell Science,Institute of Biochemistry and Cell Biology,Shang

【出处】

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中国生物化学与分子生物学会2019年全国学术会议

【发表日期】

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2019年10期

【关键词】

：

mTORC1 crystal structure protein complex

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　　The Rag/Gtr GTPases serve as a central module in the nutrient-sensing signaling network upstream of TORC1.In human,the nutrient-activated Rag heterodimer binds to mTORC1 to promote its recruitment to lysosomal membranes,where it is in a position to interact with the small GTPase Rheb that promotes its kinase activity.

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Structural insights into the Ragulator-and EGO-TC-mediated membrane tethering of the mTORC1-regulato

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