The HECT type E3 ligases are key regulators of cell growth and proliferation,and malfunctions of these enzymes are associated with a broad range of human tumors and other diseases.
L-periaxin is an important scaffold protein in nerve cells of mammals.During the development and maturation of Schwann cells,L-periaxin redistributes its subcellular localization from the nucleus to t
In the peripheral nervous system(PNS),Schwann cells(SCs)are required for the myelination of axons.Periaxin(PRX),one of the myelination proteins expressed in SCs,is critical for the normal development
Deficiency in homologous recombination repair(HRR)is frequently associated with hormone-responsive cancers,especially the epithelial ovarian cancer(EOC)which shows defects of HRR in up to half of case
Aerolysin-like proteins(ALPs)are aerolysin domain containing family of pore-forming proteins.They widely distributed in bacteria,fungi,plants and animals.
Although most natural proteins are composed exclusively of L-configuration amino acids,more and more emerging evidences showed that D-amino acids play crucial roles in sustaining the functions of prot
Studies have revealed that snake venoms from identical species in different regions differ in composition,toxicity and activity.This geographical venom variation might be caused by ontogeny,geographic
Regulation of endothelial cell adherent junctions is important to pathophysiological processes,in which vascular integrity is disrupted such as during tumor angiogenesis and chronic inflammatory condi