Robust Methods for Treatment Effect Calibration,with Application to Non-Inferiority Trials

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：nineoneone911

【摘要】

：

【作者】

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Zhiwei Zhang Lei Nie Guoxing Soon Zonghui Hu

【机构】

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Division of Biostatistics,Office of Surveillance and Biometrics,Center for Devices and Radiological

【出处】

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上海交通大学

【发表日期】

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2016年4期

【关键词】

：

active control conditional constancy covariate adjustment double robustness indi

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　　In comparative effectiveness research,it is often of interest to calibrate treatment effect estimates from a clinical trial to a target population that differs from the study population.One im-portant application is an indirect comparison of a new treatment with a placebo control on the basis of two separate randomized clinical trials: a non-inferiority trial comparing the new treatment with an active control and a historical trial comparing the active control with placebo.

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Robust Methods for Treatment Effect Calibration,with Application to Non-Inferiority Trials

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