Glutathione-responsive C2-symmetric benzene-based co-assembly hydrogels

• 作 者: WeiJi;Chuan-LiangFeng;
• 机 构: State Key Laboratory of Metal Matrix Composites,Shanghai Jiao Tong University,Shanghai 200240,China
• 出 处: The Third Symposium on Innovative Polymers for Controlled De
• 发表日期: 2014年期

　　Glutathione-responsive nano-vehicles have gained considerable interest because several intracellular compartments such as cytosol,mitochondria,and cell nucleus contain a high concentration of glutathione (GSH) tripeptides,which is 100-1000 times higher than that in extracellular fluids[1].A Glutathione-responsive hybrid low molecular weight hydrogel (LMHG) has been constructed by co-assembly of C2-symmetric benzene-based hydrogelator BG and 4,4-Dithiodipyridine (DTDP) (Fig.1a).It is found that this hybrid hydrogel could disassemble in a reductive environment at certain concentrations of glutathione.