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It is still challenging to achieve the high efficient CTC isolation and viable CTC samples,which is necessary for the subsequent molecular characterization and functional analysis,conceived to be of great significance for revealing the mechanism of tumor biology,cancer metastasis and drug sensitivity.In this present,we report high efficient capture and isolation of CTCs based on nanostructures and interfacial aptamers and antifouling molecules.The chitosan nanoparticles or nanofibers surface is firstly fabricated by electrospinning to provide a cellular compatible interface,and the "soft" substrate,further modified by PEG or pCBMA as antifouling molecules and DNA aptamer as specific capture molecule,is capable of specific capture of viable rare CTCs.