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Aim To study the effect and mechanism of Chlorogenic acid in allergic rhinitis (AR) mice.Methods AR was induced in BALB/c mice according to a published method with ovalbumin (OVA).The AR model was developed by intraperitoneal injection of adjuvant suspension on every other day for 7 times.Adjuvant suspension include 50 μg of OVA and 2mg of Al(OH)3, which were combined in 2ml of normal saline (NS).Then, the mice received a nasal drip of 10% OVA daily for 10days, and in normal control were dripped NS.After administration with 50 mg · kg1, 100 mg · kg1 and 200 ng · kg1 of Chlorogenic acid for 30min, The mice were attacked locally for 10 days.We observed behavior analysis, evaluated the weight of nosat draingage, related the index of thymus and spleen, determined the effect of Chlorogenic acid on the contents of cytokines, IgE and histamine by ELISA in AR mice and analyzed the mRNA expression of inflammatory cytokines (IL4, IL5, IL10, IFNγ) in the nasal mucosa tissues samples by RTPCR.Results Chlorogenic acid decreased the number of nosescratching events in 10min, the weight of nosal draingage, the index of spleen, the content of IL4 in nasal lavage fluid(NLF)and the contents of cytokines, lgE and histamine in serum; while increased the index of thymus, the content of IFNγin NLF, the contents of IFNγ in serum and the rate of IFNγ/IL4 ; The data showed a statistically significant upregulation of IFNγmRNA expressions and downregulation of IL4mRNA, ILSmRNA, IL10mRNA expressions after adiminstration of Chlorogenic acid.Conclusion Chlorogenic acid might exert the effect in AR mice through regulating the balance of Th1 and Th2.