【摘 要】
：
Hepatitis B virus (HBV) persistence is a fundamental process in chronic HBV infection and a key factor in all related liver diseases;however, the mechanisms have yet to be elucidated.We studied the ro
【机 构】
：
Institute of Immunology, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Li
【出 处】
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The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会)
论文部分内容阅读
Hepatitis B virus (HBV) persistence is a fundamental process in chronic HBV infection and a key factor in all related liver diseases;however, the mechanisms have yet to be elucidated.We studied the role of Toll-like receptor 2 (TLR2) in HBV persistence using a well-established HBV-carrier mouse model generated by hydrodynamically injecting an HBV1.2-containing plasmid (pAAV/HBV1.2) into mice.We found that a genetic deficiency in TLR2 improves HBV elimination, whereas activating TLR2 led to more stable HBV persistence, suggesting that TLR2 activation is critical in HBV persistence.
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